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FITC anti-human CD19 Antibody

FITC抗人CD19抗体

公司名称: BioLegend
产品编号: 302206
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T Follicular Helper Cell Coculture Assay
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2014-01-05
[Abstract]  T follicular helper (Tfh) cells constitute a distinct subset of CD4+ T cells specialized in providing help to B cells in germinal centers. Phenotypically, Tfh cells are characterized by their high expression of the chemokine receptor CXCR5 that allows their migration into B cell follicles as well as high expression of PD-1, BTLA, the co-stimulatory molecules ICOS and SLAM and the transcription factors BCL6 and cMaf. Tfh cells are the main producers of IL-21 as well as other cytokines like IL-4 and IL-10 critical for B cell survival and differentiation. Tfh cells drive somatic ... [摘要]  T滤泡辅助(Tfh)细胞构成专门提供对生发中心中的B细胞的帮助的CD4 + T细胞的不同亚群。表型上,Tfh细胞的特征在于其高趋化因子受体CXCR5的表达,其允许它们迁移到B细胞滤泡以及PD-1,BTLA,共刺激分子ICOS和SLAM以及转录因子BCL6和cMaf的高表达。 Tfh细胞是IL-21以及其他细胞因子如IL-4和IL-10对B细胞存活和分化关键的主要生产者。 Tfh细胞驱动体细胞超突变和长寿记忆B细胞和浆细胞的产生在保护性免疫的发展中具有重要作用。开发共培养系统以测量Tfh细胞介导的B细胞帮助的效果是非常感兴趣的进一步我们的Tfh-B细胞相互作用的理解,并允许操纵文化条件调查潜在影响不同的微环境信号或配体/受体相互作用可能对Tfh细胞功能。

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