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ECM Gel from Engelbreth-Holm-Swarm murine sarcoma

ECM Gel from Engelbreth-Holm-Swarm murine sarcoma

公司名称: Sigma-Aldrich
产品编号: E1270
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Tumor Cell Invasion Assay
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2012-02-05
[Abstract]  Cell invasion assays have been used to study the interactions between tumor cells and the extracellular matrix (ECM), which not only provides a structural scaffold for the cell, but also contains various biological factors for the survival and growth of the cell. ECM gel contains the basic components of the ECM that provides a structural support for the cell to grow and move. Cells can secrete enzymes that degrade certain components of the ECM to move towards chemoattractants, or to simply establish niches for growth. Metastatic tumor cells often show more invasiveness to the ECM gel due to ... [摘要]  细胞侵袭实验用来研究肿瘤细胞和胞外基质(ECM)之间的相互作用。ECM不仅为细胞提供了结构支架,同时也包含了许多细胞生存及生长过程中生物功能因子。细胞可以分泌一种酶,该酶能够降解EMC中特定的组分,从而使细胞向化学引诱剂移动,或者直接形成一种生长的状态。EMC胶模仿体内细胞外基质ECM环境,包含了支撑细胞结构的最基本的组分。转移性肿瘤细胞由于其高迁移和/或降解ECM的酶活从而表现出较强的侵袭性。

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