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Alhydrogel® adjuvant 2%

公司名称: InvivoGen
产品编号: vac-alu-250
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Instillation of Particulate Suspensions to the Lungs
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2017-11-20
[Abstract]  Inhaled fine particulates are thought to cause chronic pulmonary inflammation through the deposition of particulates into the lungs. To investigate the effect of fine particulates on the lungs, instillation of suspension of particulates into the lungs is required. This protocol describes direct injection of suspensions of fine particulates into the airway. We also show examples of typical lung immune responses after particulate administration. [摘要]  吸入的细微颗粒被认为是通过颗粒沉积到肺中引起慢性肺部炎症。 为了研究细颗粒对肺的影响,需要将颗粒悬浮液滴注到肺中。 这个协议描述了直接注入气道细粒悬浮物。 我们还展示了颗粒给药后典型的肺部免疫反应的例子。

【背景】近来,许多研究已经证明,诸如柴油机尾气颗粒物,沙尘和颗粒物质2.5(PM2.5)之类的颗粒污染物参与导致肺癌或过敏性哮喘的慢性肺部炎症。 流行病学分析显示,颗粒物空气污染增加与哮喘住院率增加有关。 通常,在吸入时,已知细颗粒如PM2.5深入肺部。 将颗粒悬浮液滴注到肺中已被广泛用于理解由沉积颗粒诱导的肺部炎症(Morimoto等人,2016)。

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