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Sunlite 24 Watt Colored Spiral

公司名称: Sunlite
产品编号: SL24/R
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Context-driven Salt Seeking Test (Rats)
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2018-04-05
[Abstract]  Changes in reward seeking behavior often occur through incremental learning based on the difference between what is expected and what actually happens. Behavioral flexibility of this sort requires experience with rewards as better or worse than expected. However, there are some instances in which behavior can change through non-incremental learning, which requires no further experience with an outcome. Such an example of non-incremental learning is the salt appetite phenomenon. In this case, animals such as rats will immediately seek out a highly-concentrated salt solution that was previously ... [摘要]  基于预期和实际发生的差异,通过增量学习经常发生奖励寻求行为的变化。这种行为灵活性要求奖励的经验比预期更好或更差。然而,在一些情况下,行为可以通过非增量学习来改变,这不需要进一步的经验与结果。这种非增量学习的例子是盐食欲现象。在这种情况下,像老鼠这样的动物会立即寻找高浓度的盐溶液,这种盐溶液在处于新的钠剥夺状态时以前是不受欢迎的。重要的是,这种适应性寻盐行为发生,尽管大鼠从未在耗尽状态下尝过盐,因此从来没有尝到过它是一种非常理想的奖励。

以下协议是调查神经电路介导自适应寻盐使用条件位置偏好(CPP)程序的方法。该程序旨在提供发现神经回路介导寻盐和盐消耗以补充缺钠后身体缺陷之间可能的解离的机会。另外,这个程序适合于结合许多神经生物学技术来研究这种行为的大脑基础。

【背景】盐食欲现象最早是由里希特(Richter,1936)发现的,他发现大鼠开始立即食用1%的盐溶液,与肾上腺切除术后的2瓶选择试验中的水相比,其量更大,因此体内钠耗竭。最近,Robinson和Berridge(2013)已经表明,在没有盐的情况下钠消耗之前,这种盐寻求行为的立即增加发生在离散的盐配对线索之后,因为它已被尝试作为理想的奖励。此外,在钠耗竭后,情景线索也观察到了适应性寻盐(Stouffer和White,2005)。

在大脑中,有明确的证据表明杏仁核的中心核(Galaverna ...

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