| IgE-mediated Chronic Allergic Inflammation (IgE-CAI)
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Author:
Date:
2012-10-05
[Abstract] This system is one of a chronic allergic inflammation model. A single subcutaneous injection of antigens elicits a delayed-type response manifested by ear swelling. The entire response consists of three phases: Immediate, late, and chronic. The early-phase swelling peak within 1 h after allergen challenge is followed by the late-phase swelling 6-10 h late. Importantly, the ear swelling at the late-phase started on day2 and peak on day4. This late-phase ear swelling response is defined as IgE-mediated chronic allergic inflammation (IgE-CAI) and mainly regulated by basophils.
[摘要] 该实验方案的中文版正在准备中．．．
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| Mast Cell Dependent Airway Hyperresponsiveness (AHR)
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Author:
Date:
2012-10-05
[Abstract] Asthma is a complex phenotype that involves multiple mechanisms, including adaptive and innate immunity as well as physiological and mechanical changes in the airways. In the models of asthma induced by sensitization and aerosolized allergen exposure in the absence of adjuvant, mast cells facilitate the development of in ammation and airway hyper-responsiveness. This model is useful to analysis of function of mast cells in AHR.
[摘要] 该实验方案的中文版正在准备中．．．
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