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APC Mouse Anti-Human CD40

APC鼠抗人CD40

公司名称: BD
产品编号: 555591
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Generation and Maturation of Human Monocyte-derived DCs
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2014-08-05
[Abstract]  Dendritic cells (DC) are antigen-presenting cells, which play a critical role in the regulation of the adaptive immune response. They act as a bridge between the innate and the adaptive immune systems. An approach to study their function and potentiality is to generate DC-like cells by culturing CD14+ monocyte-enriched peripheral blood mononuclear cells (PBMC). In the presence of GM-CSF and IL-4, these cultures give rise to large numbers of DC-like cells. Generating human-DC from PBMC is a useful tool to study biological functions of human DC. [摘要]  树突状细胞(DC)是抗原呈递细胞,其在适应性免疫应答的调节中起关键作用。 它们作为先天免疫系统和适应性免疫系统之间的桥梁。 研究它们的功能和潜力的方法是通过培养富集CD14 +单核细胞的外周血单核细胞(PBMC)产生DC样细胞。 在GM-CSF和IL-4存在下,这些培养物产生大量的DC样细胞。 从PBMC产生人类DC是研究人类DC的生物学功能的有用工具。

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