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Author:
Date:
2015-07-05
[Abstract] Mouse models have demonstrated utility in delineating the mechanisms underlying many aspects of malaria immunology and physiology. The most common mouse models of malaria employ the rodent-specific parasite species Plasmodium berghei, P. yoelii, and P. chabaudi, which elicit distinct pathologies and immune responses and are used to model different manifestations of human disease. In vitro culture methods are not well developed for rodent Plasmodium parasites, which thus require in vivo maintenance. Moreover, physiologically relevant ...
[摘要] 小鼠模型已经证明了用于描绘疟疾免疫学和生理学的许多方面的机制的效用。 最常见的疟疾小鼠模型使用啮齿动物特异性寄生虫物种伯氏疟原虫 。 yoelii 和 P。 chabaudi ，其引起不同的病理学和免疫应答，并用于模拟人类疾病的不同表现。 体外培养方法对于啮齿动物疟原虫寄生虫不是很好发展，因此需要在体内维持。 此外，生理相关的免疫过程最好在体内研究。 在这里，我们详细的感染小鼠与疟原虫，维持寄生虫体内，并监测寄生虫水平和健康参数整个感染的过程。
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