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Author:
Date:
2015-08-05
[Abstract] The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid in the central nervous system. The blood–brain barrier allows the passage of water, some gases, and lipid soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. This protocol provides a full, detailed method for measuring blood-brain-barrier permeability of mice with Evans blue (EB), that leakage was used to assess blood-brain barrier (BBB) ...
[摘要] 血脑屏障（BBB）是一种高度选择性的渗透性屏障，其将循环血液与中枢神经系统中的脑细胞外液分离。 血脑屏障允许通过被动扩散的水，一些气体和脂溶性分子的通过，以及对神经功能至关重要的分子如葡萄糖和氨基酸的选择性转运。 该方案提供了一种全面详细的测量Evans blue（EB）小鼠血脑屏障通透性的方法，该方法用于评估血脑屏障（BBB）通透性（样品：前扣带皮质，ACC）。
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