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Author:
Date:
2014-10-05
[Abstract] Cognitive flexibility, the higher-order cognition involving reversal learning, has been defined as having the ability to shift one’s previous thoughts or actions to new situations depending on situational demands. Studies of neuropsychiatric disorders such as autism spectrum disorder (ASD) showed that restricted and repetitive patterns of activities are associated with the impairments of cognitive flexibility. Some behavioral tasks including attentional set-shifting task are used to assess cognitive flexibility in mouse models for psychiatric disorders (Birrell and Brown, 2000; Colacicco et ...
[摘要] 认知灵活性，涉及反向学习的高阶认知，已被定义为具有根据情境需求将一个先前的想法或行动转移到新的情况的能力。 神经精神疾病如自闭症谱系障碍（ASD）的研究表明，受限和重复的活动模式与认知灵活性的损伤有关。 包括注意集移位任务的一些行为任务用于评估用于精神障碍的小鼠模型中的认知灵活性（Birrell和Brown，2000; Colacicco等人，2002）。 在这里，我们提出了一个双选择挖掘测试，这是简化和修改从集移位任务，使用小鼠来研究逆转学习（黄等人。，2014）。
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