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β-Actin (13E5) Rabbit mAb

β-肌动蛋白(13E5)兔mAb

公司名称: Cell Signaling Technology
产品编号: 4970
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Western Blot for Detecting Phosphorylated STAT3
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2011-08-20
[Abstract]  The STAT3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. STAT3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Western blot is most commonly used to detect the activation of STAT3 by using an antibody that is specific for the phosphorylated tyrosine705. [摘要]  Stat3转录因子是许多细胞因子和生长因子受体中重要的信号分子,它在许多人类的肿瘤细胞中持续激活,具备潜在的致癌能力和抗凋亡能力。Stat3通过705位酪氨酸磷酸化被激活,进而诱导它的二聚化,核定位以及DNA结合功能。STAT3的活性经常通过能识别705位酪氨酸磷酸化的抗体来检测。

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